People often ask me about the transition that the Flickr team (and I) have been through as a result of coming under the wing of Yahoo! and leaving Vancouver for the foggy streets of San Francisco.
I think as long as I live somewhere where people speak the same language as I do, I could pretty much live anywhere. Not to say that I couldn't live, say, in Italy. It was easy to find a place here and settle in. Apart from the effin horrific commute, it's rosy.
But! In terms of work life, I think The Adventures of ACTION ITEM!
explains quite a bit.